Origins of Cell Compartmentalization

Two of the eukaryotic cell's most important organelles were once free-living cells in their own right. The endosymbiotic theory holds that mitochondria and chloroplasts descend from prokaryotes that were engulfed by a larger ancestral host cell — and instead of being digested, they stayed. An aerobic bacterium taken up by that host became the mitochondrion; a photosynthetic cyanobacterium, taken up later in the lineage that became plants and algae, became the chloroplast. Compartmentalization did not have to be built from scratch. In these two cases it was acquired, one whole cell absorbed into another.

The evidence is written into the organelles themselves. Mitochondria and chloroplasts carry their own small, circular DNA — the arrangement bacteria use, not the linear chromosomes of the nucleus. They make their own proteins on ribosomes that resemble bacterial ribosomes more than the cell's own. They are wrapped in a double membrane, the inner one a relic of the original prokaryote and the outer one from the host's engulfing vesicle. And they divide on their own by a fission-like process, independent of the cell's division. Each trait is a fingerprint left by a former guest.

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The common mistake here is treating the theory as a story about the whole cell rather than these two organelles: assuming the nucleus, endoplasmic reticulum, or Golgi arose the same way. They did not — those compartments formed by infolding of the cell's own membrane, and they carry none of the endosymbiotic fingerprints. Only mitochondria and chloroplasts have their own genome, their own ribosomes, and a double membrane, because only they began as separate cells. Every scenario in this topic asks you to read the evidence and say which compartments the endosymbiotic theory actually explains — and why.